Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack on an hidden munitions depot in Syrian territory used by the Islamic State group (IS), per a report from the British defence ministry.
The site, identified by reconnaissance, was thought to be storing arms and explosives, the statement said, and was located in mountains just to the north of the historic site of Palmyra in central Syria.
"Our fighter planes utilized Paveway IV guided bombs to hit a series of approach shafts down to the depot... preliminary assessments are that the objective was successfully hit," the MoD said.
There was no evidence of any harm to civilians in the attack conducted Saturday night and every plane involved made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - imposed jihadist rule over parts of Iraq and Syria before its territorial defeat in 2019.
"This strike underscores our UK leadership, and commitment to stand shoulder to shoulder with our allies, to eliminate any revival of Daesh and their dangerous and violent ideologies in the region," UK Defence Secretary John Healey remarked.
RAF aircraft have carried out surveillance missions over Syria to "deter any attempted comeback" of Islamic State following its routing at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces who took part in this operation for their expertise and their valour," the Defence Secretary commented. "Including them were a great many British personnel stationed over the festive period. This action, to eliminate terrorist threats who endanger our security, shows how UK forces are ready to step up, throughout the year, protecting the UK at home and powerful internationally."
Last December, the US military carried out what it termed a "major assault" targeting Islamic State objectives in Syria, following an ambush killed two US servicemembers and a civilian interpreter in Palmyra.
The United Nations estimates Islamic State still maintains roughly 5-7 thousand fighters in Iraq and Syria.